antineutrophil cytoplasmic autoantibodi es in rheumatoid arthritis

Authors

m vodjgani from the department of immunology. faculty of medicine. tehran university of medical sciences. tehran. i.r. iran.

ke ansari

j hajati

abstract

antineutrophil cytoplasmic autoantibodies (anca) were detected in patients with autoimmune and vascular diseases such as wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. indirect immunofluorescence (iif) technique was employed to detect these autoantibodies. by this method, two general patterns of anca were seen: a cytoplasmic (canca) and a perinuclear form (p-anca). these antibodies were also observed in rheumatoid arthritis (ra) but their prevalence and clinical significance have not been determined. in this study the presence of anca in 52 ra patients (10 males and 42 females) and its relationship with disease activity was evaluated. 26.9% of patients were anca-positive, 36% of whom had c-anca and 64% a p-anca pattern. the results also showed that there is no significant correlation between anca titer and disease activity (p

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODI ES IN RHEUMATOID ARTHRITIS

Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in patients with autoimmune and vascular diseases such as Wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. Indirect immunofluorescence (IIF) technique was employed to detect these autoantibodies. By this method, two general patterns of ANCA were seen: a cytoplasmic (cANCA) and a perinuclear form ...

full text

Antineutrophil cytoplasmic antibodies in rheumatoid arthritis patients.

We determined the occurrence of antineutrophil cytoplasmic antibodies (ANCAs) and their specificities in 77 rheumatoid arthritis (RA) patients and compared them with 25 patients with psoriatic arthritis (Pso), 19 with drug-induced lupus erythematosus (DI-LE) and 11 with systemic lupus erythematosus (SLE). Thirty-two percent of RA patients had positive indirect immunofluorescence (IIF) stains (P...

full text

Alveolar hemorrhage associated with antineutrophil cytoplasmic antibodies in rheumatoid arthritis.

A 65-year-old woman with previously known rheumatoid arthritis and chronic renal failure of possible glomerular origin was admitted to the hospital because of hemoptysis and respiratory insufficiency. Antineutrophil cytoplasmic antibodies (ANCAs) with antimyeloperoxidase activity were detected in her serum. The lung biopsy specimen evidenced alveolar hemorrhage. Under immunosuppressive therapy ...

full text

Antineutrophil Cytoplasmic Antibodies in Patients with Pulmonary Tuberculosis

Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic sy...

full text

Antineutrophil cytoplasmic antibodies.

Antineutrophil cytoplasmic antibodies (ANCA) are predominantly IgG autoantibodies directed against constituents of primary granules of neutrophils and monocytes lysosomes. Although several antigenic targets have been identified, those ANCA directed to proteinase 3 or myeloperoxidase are clinically relevant, whereas the importance of other ANCA remains unknown. Both are strongly associated with ...

full text

My Resources

Save resource for easier access later


Journal title:
medical journal of islamic republic of iran

جلد ۱۳، شماره ۴، صفحات ۲۶۵-۲۶۷

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023